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However, PHGDH deletioninduced GSH synthesis deficiency may lead to macrophages being in an anoxic state, which could increase the release of mtROS and promote mitochondrial biogenesis through an mtROSHIF-1SP1/NRF1 axis

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Moreover, the potential of NLRP3 inhibitors such as MCC950 and colchicine in suppressing tumor growth has been demonstrated in experimental models of head and neck squamous cell carcinoma and gastric cancer (Zhang T